CALR Gene CALR selective sequencing of exon 9 Genetic Test
Genetic testing plays a crucial role in the diagnosis and management of various genetic disorders. One such test is the CALR Gene CALR selective sequencing of exon 9 Genetic Test offered by DNA Labs UAE.
Test Details
The CALR (calreticulin) gene is responsible for encoding a calcium-binding protein involved in important cellular processes such as protein folding and calcium homeostasis. Mutations in the CALR gene have been linked to certain blood disorders, particularly myeloproliferative neoplasms (MPNs) like essential thrombocythemia (ET) and primary myelofibrosis (PMF).
Specifically, the CALR exon 9 mutation, characterized by a 52-base pair deletion and insertion in exon 9 of the CALR gene, has been identified in a significant number of MPN patients. To detect and analyze this mutation, DNA Labs UAE offers the CALR selective sequencing of exon 9 Genetic Test using next-generation sequencing (NGS) technology.
NGS is a high-throughput sequencing method that enables the simultaneous sequencing of multiple DNA fragments, providing detailed information about genetic variations present in a sample. By selectively sequencing exon 9 of the CALR gene, this test accurately detects the presence or absence of the CALR exon 9 mutation and provides information about the specific mutation type.
Components and Cost
The CALR Gene CALR selective sequencing of exon 9 Genetic Test is priced at 4400.0 AED. The test requires a blood sample, extracted DNA, or one drop of blood on an FTA card.
Report Delivery and Method
After the sample is collected, the report is delivered within 3 to 4 weeks. The test utilizes NGS technology for accurate and efficient analysis.
Test Type and Doctor
The CALR Gene CALR selective sequencing of exon 9 Genetic Test falls under the category of cancer genetic testing. It is typically recommended and performed by oncologists.
Test Department and Pre Test Information
The test is conducted in the Genetics department of DNA Labs UAE. Before undergoing the CALR Gene CALR selective sequencing of exon 9 Genetic Test, it is important for the patient to provide their clinical history. Additionally, a genetic counseling session may be required to draw a pedigree chart of family members affected by the CALR exon 9 mutation.
Importance and Applications
The CALR exon 9 NGS genetic test serves multiple purposes in the diagnosis and management of MPNs. It helps identify the presence of the CALR exon 9 mutation, aiding in the classification of MPNs and monitoring disease progression and treatment response. Furthermore, the test provides valuable information about the specific mutation type, assisting in determining the most appropriate treatment approach for patients with MPNs.
In conclusion, the CALR Gene CALR selective sequencing of exon 9 Genetic Test offered by DNA Labs UAE is a vital tool in the molecular diagnosis and management of MPNs. With its ability to accurately detect the CALR exon 9 mutation and provide personalized treatment strategies, this test plays a significant role in improving patient outcomes.
| Test Name | CALR Gene CALR selective sequencing of exon 9 Genetic Test |
|---|---|
| Components | |
| Price | 4400.0 AED |
| Sample Condition | Blood or Extracted DNA or One drop Blood on FTA Card |
| Report Delivery | 3 to 4 Weeks |
| Method | NGS Technology |
| Test type | Cancer |
| Doctor | Oncologist |
| Test Department: | Genetics |
| Pre Test Information | Clinical History of Patient who is going for CALR Gene CALR, selective sequencing of exon 9 NGS Genetic DNA Test. A Genetic Counselling session to draw a pedigree chart of family members affected with CALR Gene CALR, selective sequencing of exon 9 NGS Genetic DNA Test gene CALR |
| Test Details |
CALR (calreticulin) is a gene that encodes a calcium-binding protein involved in various cellular processes, including protein folding and calcium homeostasis. Mutations in the CALR gene have been associated with certain blood disorders, particularly myeloproliferative neoplasms (MPNs) such as essential thrombocythemia (ET) and primary myelofibrosis (PMF). One specific mutation in the CALR gene, known as the CALR exon 9 mutation, has been found to be present in a significant proportion of patients with MPNs. This mutation involves a 52-base pair deletion and insertion in exon 9 of the CALR gene, leading to a frameshift and subsequent production of a mutant CALR protein. Selective sequencing of exon 9 of the CALR gene using next-generation sequencing (NGS) technology allows for the detection and analysis of the CALR exon 9 mutation. NGS is a high-throughput sequencing method that enables the simultaneous sequencing of multiple DNA fragments, providing detailed information about genetic variations present in a sample. The CALR exon 9 NGS genetic test is used to identify the presence of the CALR exon 9 mutation in individuals suspected of having MPNs. This test can help in the diagnosis and classification of MPNs, as well as in monitoring disease progression and treatment response. By selectively sequencing exon 9 of the CALR gene, the test can accurately detect the presence or absence of the CALR exon 9 mutation and provide information about the specific mutation type. This information can aid in determining the appropriate treatment approach for patients with MPNs. Overall, the CALR exon 9 NGS genetic test is a valuable tool in the molecular diagnosis and management of MPNs, allowing for precise identification of the CALR exon 9 mutation and facilitating personalized treatment strategies. |
