Test Price
2,800 AED✅ Home Collection Available
MLH3 Gene Colorectal Cancer, Hereditary Nonpolyposis Type 7 (Lynch Syndrome) Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 15189 Accredited NGS Processing.
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation from our Consultant Medical Genetics.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This advanced NGS-based genetic test analyzes the MLH3 gene for pathogenic variants causing Lynch syndrome type 7, guiding colorectal cancer risk management. The test utilizes next-generation sequencing to detect single nucleotide variants, insertions, deletions, and copy number variations across the entire coding region of the MLH3 gene.
| Feature | Our MLH3 NGS Test | Closest Alternative (Sanger Sequencing / Targeted) |
|---|---|---|
| Methodology | NGS (Next‑Generation Sequencing) full‑gene analysis | Sanger sequencing or MLPA for limited exons |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks (often batched) |
| Detection Rate | >99.9% for SNVs, indels, and copy number variants | ~95% for SNVs, may miss large rearrangements |
| Interpretation | Includes ACMG variant classification & genetic counseling note | Basic report without comprehensive counseling support |
Physician Insight & Safety Protocols
Note from Lina Osama Zaki Quteineh (Consultant Medical Genetics | DHA Registration ID: 9294403): “Understanding your genetic predisposition to colorectal cancer can be life‑saving. This test offers clarity, but results must always be interpreted alongside your personal and family medical history. I encourage you to discuss findings with a specialized oncologist or genetic counselor to design a proactive screening plan.”
Required Clinical Precautions & Informed Consent
Exclusion Criteria & Emergency Red Flags
- Inability to provide valid informed consent (required under Federal Decree-Law No. 4 of 2016 on Medical Liability and UAE PDPL for genetic data).
- Recent bone marrow transplant or blood transfusion within the last 2 weeks (may affect germline DNA integrity).
- Unstable acute medical condition requiring urgent inpatient care.
- Parental/legal guardian consent mandatory for minors.
- Seek emergency care immediately if you experience sudden severe abdominal pain, rectal bleeding, or signs of bowel obstruction.
Patient FAQ & Clinical Guidance
1. What is the MLH3 gene test for Lynch syndrome?
MLH3 gene testing detects hereditary mutations causing Lynch syndrome type 7 and colorectal cancer risk. It analyzes the entire coding region of the MLH3 gene using next‑generation sequencing to identify pathogenic variants that significantly raise the lifetime chance of colon and other cancers.
2. Who should consider this test?
Anyone with multiple relatives affected by colon or uterine cancer before age 50 should consider MLH3 genetic testing. Individuals who have a personal history of colorectal polyps or belong to a family with known Lynch syndrome mutations also benefit from early screening.
3. How is the test performed and what is the turnaround time?
A certified phlebotomist visits your home between 8 AM and 11 PM to draw a small blood sample, which is transported under cold‑chain conditions to our ISO‑accredited lab. NGS genetic sequencing delivers MLH3 results in 3 to 4 weeks from the date of sample collection.
UAE Regulatory & Data Privacy Adherence
Data Protection & Compliance Framework
This laboratory test and associated personal data processing strictly adhere to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Genetic information is encrypted, access-controlled, and processed only for diagnostic purposes. All procedures involving patient consent and clinical safety are conducted in compliance with Federal Decree-Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | MLH3 Gene Colorectal Cancer, Hereditary Nonpolyposis Type 7 (Lynch Syndrome) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Blood (Whole Blood) – EDTA Tube |
| Methodology Used | Next-Generation Sequencing (NGS) – Full Gene Analysis |
| ICD-10-CM Code | Z15.08 |
| LOINC Code | 82378-1 |
| DHA Facility License & Laboratory Address | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians