FISH – 11q23 OR LSI MLL GENE BREAKAPART Test
Cost: AED 950.0
Symptoms and Diagnosis
The FISH – 11q23 or LSI MLL gene break apart test is a genetic test primarily used in the diagnosis and monitoring of certain types of leukemia, such as acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). This test detects rearrangements in the MLL (Mixed Lineage Leukemia) gene on chromosome 11q23.
The MLL gene is responsible for encoding proteins that play a crucial role in normal cell development and differentiation. However, when the MLL gene becomes rearranged or broken apart, it can result in the formation of abnormal fusion genes. These fusion genes can lead to the uncontrolled growth and proliferation of cancer cells, contributing to the development of leukemia.
The FISH – 11q23 or LSI MLL gene break apart test uses fluorescently labeled DNA probes that bind specifically to the MLL gene region. By analyzing the pattern of fluorescence under a microscope, the test can detect whether the MLL gene has undergone a rearrangement or breakage.
If a rearrangement or breakage in the MLL gene is detected, it may indicate a higher risk of treatment resistance or relapse. This information can help guide treatment decisions, such as the use of targeted therapies or more aggressive treatment approaches.
Test Details
- Test Name: FISH – 11q23 OR LSI MLL GENE BREAKAPART Test
- Components: Chromosome & FISH analysis Requisition Form (Form 17)
- Price: AED 950.0
- Sample Condition: 5 mL (3 mL min.) whole blood OR 4 mL (2 mL min.) Bone Marrow from 2 Green Top (Sodium Heparin) tubes. Ship at 18-22°C. DO NOT FREEZE.
- Report Delivery: Sample Daily by 4 pm; Report 4 Working days
- Method: FISH
- Test Type: Leukemia
- Doctor: Oncologist, Hematologist
- Test Department: CYTOGENETICS
- Pre Test Information: Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory.
Conclusion
The FISH – 11q23 or LSI MLL gene break apart test is an important tool in the genetic analysis of leukemia, providing valuable information for personalized treatment planning and monitoring of the disease.
| Test Name | FISH – 11q23 OR LSI MLL GENE BREAKAPART Test |
|---|---|
| Components | |
| Price | 950.0 AED |
| Sample Condition | 5 mL (3 mL min.) whole blood OR 4 mL (2 mL min.) Bone Marrow from 2 Green Top (Sodium Heparin) tubes. Ship at 18-22?\u00f8C. DO NOT FREEZE. Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory. |
| Report Delivery | Sample Daily by 4 pm; Report 4 Working days |
| Method | FISH |
| Test type | Leukemia |
| Doctor | Oncologist, Hematologist |
| Test Department: | CYTOGENETICS |
| Pre Test Information | Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory. |
| Test Details | The FISH – 11q23 or LSI MLL gene break apart test is a genetic test used to detect rearrangements in the MLL (Mixed Lineage Leukemia) gene on chromosome 11q23. This test is primarily used in the diagnosis and monitoring of certain types of leukemia, such as acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). The MLL gene is responsible for encoding proteins that play a crucial role in normal cell development and differentiation. However, when the MLL gene becomes rearranged or broken apart, it can result in the formation of abnormal fusion genes. These fusion genes can lead to the uncontrolled growth and proliferation of cancer cells, contributing to the development of leukemia. The FISH – 11q23 or LSI MLL gene break apart test uses fluorescently labeled DNA probes that bind specifically to the MLL gene region. By analyzing the pattern of fluorescence under a microscope, the test can detect whether the MLL gene has undergone a rearrangement or breakage. The results of the test can provide valuable information about the prognosis and treatment options for individuals with leukemia. If a rearrangement or breakage in the MLL gene is detected, it may indicate a higher risk of treatment resistance or relapse. This information can help guide treatment decisions, such as the use of targeted therapies or more aggressive treatment approaches. Overall, the FISH – 11q23 or LSI MLL gene break apart test is an important tool in the genetic analysis of leukemia, providing valuable information for personalized treatment planning and monitoring of the disease. |
