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ALL FISH PANEL FISH BCR-ABL TEL-AML1 MLL E2A Test

3,200 د.إ

-20%

The “All Fish Panel Fish BCR-ABL TEL-AML1 MLL E2A Test” is a comprehensive diagnostic tool used in medical genetics and oncology to detect specific genetic abnormalities associated with various forms of leukemia. This test is particularly crucial for identifying chromosomal translocations and gene fusions that play a significant role in the development and progression of leukemia. The panel includes tests for BCR-ABL, which is associated with chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL); TEL-AML1 (ETV6-RUNX1), linked to childhood acute lymphoblastic leukemia; MLL (Mixed Lineage Leukemia gene rearrangements), associated with various types of leukemia; and E2A (TCF3-PBX1), also related to acute lymphoblastic leukemia.

Performed at DNA Labs UAE, a leading facility in genetic testing and diagnostics, the test involves the use of fluorescence in situ hybridization (FISH) technology. This method enables precise detection of genetic abnormalities by using fluorescent probes that bind to specific DNA sequences on chromosomes, allowing for the visualization of genetic changes under a fluorescence microscope.

The cost of the test is 3200 AED (United Arab Emirates Dirham), reflecting the sophisticated technology and expertise required to conduct this analysis. The results from this test can provide critical information for the diagnosis, prognosis, and treatment planning of leukemia, helping healthcare professionals to tailor treatments according to the genetic profile of the patient’s disease.

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ALL FISH PANEL FISH BCRABL TELAML1 MLL E2A Test – Cost, Symptoms, Diagnosis

Welcome to the DNA Labs UAE blog, where we provide detailed information about our genetic testing services. In this blog post, we will discuss the ALL FISH PANEL FISH BCRABL TELAML1 MLL E2A Test, its cost, symptoms, diagnosis, and other important details.

Test Name: ALL FISH PANEL FISH BCRABL TELAML1 MLL E2A Test

  • Components: Sodium Heparin Vacutainer (2ml)
  • Price: 3200.0 AED
  • Sample Condition: Bone marrow / Peripheral blood (Transport immediately)
  • Report Delivery: 5-7 days
  • Method: FISH
  • Test type: Genetics
  • Doctor: Oncology
  • Test Department:

Pre Test Information

The ALL FISH PANEL FISH BCRABL TELAML1 MLL E2A Test can be done with a doctor’s prescription. However, please note that the prescription is not applicable for surgery and pregnancy cases or people planning to travel abroad.

Test Details

The ALL Fish Panel is a diagnostic test used in the field of hematology to detect specific genetic abnormalities in patients with acute lymphoblastic leukemia (ALL). It is a type of fluorescence in situ hybridization (FISH) test that focuses on four specific gene rearrangements: BCR/ABL, TEL/AML1, MLL, and E2A.

1. BCR/ABL:

This gene rearrangement is commonly found in a subtype of ALL called Philadelphia chromosome-positive ALL (Ph+ ALL). It is characterized by the fusion of the BCR gene on chromosome 22 with the ABL gene on chromosome 9. The resulting BCR/ABL fusion gene produces a protein that promotes uncontrolled cell growth and division, leading to the development of leukemia.

2. TEL/AML1:

This gene rearrangement is also known as the t(12;21) translocation. It involves the fusion of the TEL gene on chromosome 12 with the AML1 gene on chromosome 21. The TEL/AML1 fusion gene is associated with a favorable prognosis in pediatric ALL, as it is commonly found in children with precursor B-cell ALL.

3. MLL:

The MLL gene, also known as the KMT2A gene, is located on chromosome 11. Rearrangements involving the MLL gene are common in infant ALL and are associated with a poor prognosis. The MLL gene rearrangement can result in the fusion of MLL with various partner genes, leading to the production of abnormal fusion proteins that disrupt normal cellular processes.

4. E2A:

The E2A gene, also known as the TCF3 gene, is located on chromosome 19. Rearrangements involving the E2A gene are commonly found in precursor B-cell ALL. The most common fusion partner for E2A is the PBX1 gene, resulting in the formation of the E2A-PBX1 fusion gene. This fusion gene is associated with a poor prognosis in ALL.

The ALL Fish Panel is performed on bone marrow or peripheral blood samples to detect these specific gene rearrangements. The test uses fluorescent probes that bind to the target genes and produce a signal that can be visualized under a fluorescence microscope. The presence or absence of these gene rearrangements helps in determining the subtype of ALL and guiding treatment decisions.

If you suspect any symptoms related to acute lymphoblastic leukemia (ALL) or require further information about the ALL FISH PANEL FISH BCRABL TELAML1 MLL E2A Test, please consult with our oncology specialist.

Test Name ALL FISH PANEL FISH BCRABL TELAML1 MLL E2A Test
Components Sodium Heparin Vacutainer (2ml)
Price 3200.0 AED
Sample Condition Bone marrow \/ Peripheral blood (Transport immediately)
Report Delivery 5-7 days
Method FISH
Test type Genetics
Doctor Oncology
Test Department:
Pre Test Information ALL FISH PANEL FISH BCR/ABL, TEL/AML1, MLL, E2A]) can be done with a Doctors prescription. Prescription is not applicable for surgery and pregnancy cases or people planing to travel abroad.
Test Details

The ALL Fish Panel is a diagnostic test used in the field of hematology to detect specific genetic abnormalities in patients with acute lymphoblastic leukemia (ALL). It is a type of fluorescence in situ hybridization (FISH) test that focuses on four specific gene rearrangements: BCR/ABL, TEL/AML1, MLL, and E2A.

1. BCR/ABL: This gene rearrangement is commonly found in a subtype of ALL called Philadelphia chromosome-positive ALL (Ph+ ALL). It is characterized by the fusion of the BCR gene on chromosome 22 with the ABL gene on chromosome 9. The resulting BCR/ABL fusion gene produces a protein that promotes uncontrolled cell growth and division, leading to the development of leukemia.

2. TEL/AML1: This gene rearrangement is also known as the t(12;21) translocation. It involves the fusion of the TEL gene on chromosome 12 with the AML1 gene on chromosome 21. The TEL/AML1 fusion gene is associated with a favorable prognosis in pediatric ALL, as it is commonly found in children with precursor B-cell ALL.

3. MLL: The MLL gene, also known as the KMT2A gene, is located on chromosome 11. Rearrangements involving the MLL gene are common in infant ALL and are associated with a poor prognosis. The MLL gene rearrangement can result in the fusion of MLL with various partner genes, leading to the production of abnormal fusion proteins that disrupt normal cellular processes.

4. E2A: The E2A gene, also known as the TCF3 gene, is located on chromosome 19. Rearrangements involving the E2A gene are commonly found in precursor B-cell ALL. The most common fusion partner for E2A is the PBX1 gene, resulting in the formation of the E2A-PBX1 fusion gene. This fusion gene is associated with a poor prognosis in ALL.

The ALL Fish Panel is performed on bone marrow or peripheral blood samples to detect these specific gene rearrangements. The test uses fluorescent probes that bind to the target genes and produce a signal that can be visualized under a fluorescence microscope. The presence or absence of these gene rearrangements helps in determining the subtype of ALL and guiding treatment decisions.